BK Virus-Associated Hemorrhagic Cystitis in Children Suffering from Malignancies: Report of Three Cases

BK virus-associated hemorrhagic cystitis (HC) is frequent in patients undergoing bone marrow transplantation, but it rarely occurs among other immunosuppressed patients particularly in those who are receiving chemotherapy for hematologic malignancies. Herein, we report three children with malignancies suffering from hemorrhagic cystitis due to BK virus infection who were successfully improved. Early detection of BK virus using RT-PCR technique was undertaken. With administration of antiviral agents; specifically, IVIG or leflunomide, BK virus-associated HC could be successfully managed in children affected by malignancies and consequently, chemotherapy of underlying disorder might be continued after virus elimination.